Inhibition of sickling in erythrocytes by amino acids
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چکیده
منابع مشابه
Inhibition of sickling in erythrocytes by amino acids.
Sickling of erythrocytes was rapidly and quantitatively inhibited at room temperature by 3.8 mM homoserine, asparagine, and glutamine but by no other amino acid.
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To test the antisickling activity of pyridoxal, we compared the oxygen affinity and the percent sickling at low PO2 of untreated erythrocytes with values for cells from the same blood sample incubated with pyridoxal, glyceraldehyde, or pyridoxine. Pyridoxal increased oxygen affinity much more than glyceraldehyde. 20 mM pyridoxal and glyceraldehyde had equivalent antisickling activity. At PO2 le...
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ژورنال
عنوان ژورنال: Blood
سال: 1975
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v45.1.45.bloodjournal45145